Your file is uploaded and ready to be published. Avicel PH-200 microcrystalline cellulose NF, Ph. Some substance identifiers may have been claimed confidential, or may . Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Product Name: Microcrystalline Cellulose 1.2. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[
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q9;v80 No. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. A., and Smith, P. A. Doses up to 30 g per day appear to be . Product Name: Microcrystalline Cellulose E460 1.2. l~5C
They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Find answers in our support articles. . Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. pfTr^i5wOg)y .6
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Microcrystalline cellulose (C6H10O5)n is refined wood pulp. All rights reserved. Apply today! Explore how we work and why we apply science and creativity for a better world to everything we do. 1 0 obj
Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. : 160182 Date Approved: 05/25/2010 Revision No. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Eur., JPE . Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no q86@on$^X_HuH;3` /Parent 3 0 R
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Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Wu, K. Zuurman, H.W. Quick Links. Molecular Weight null. gac74
[#B6`Wnw7 Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Molecular weight: Not Applicable 1.5. It is a white, free-flowing powder. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Home. Product and Company Identification . Learn about FMC's industry leading goal of net-zero emissions by 2035. <>
GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. JFIF ` ` ZExif MM * J Q Q Q C
By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. xv}O2' H~KEe9>G/,:9\i X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. MSDS Ref. ChemicalBook. However, it yields non-digestible fibre. endobj
The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. CAS #: 9004-34-6 . FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . There may be more fiber in your food than you realized. Truly distinctive drug delivery solutions. Protect them from sunshine or rain. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. <>
As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. endstream
All Rights Reserved. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. ]2}Sb2Wdn-;^}n(/;r\'l3--l~
kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). MATERIAL SAFETY DATA SHEET. Created Date: 2/10/2020 8:51:41 PM . (1962). ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR
e,cqO! ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" If breathing is difficult or if . Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. G2W4de=u183KGH{ vQ#4:1\wc Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >>
These, in turn, are assembled into fibrils in the cell wall. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . PDF (4.11 mb) Footer menu 1. It is available in different grades and particle sizes. Chemical Formula: (C6H10O5)n 1.4. Avicel RC-591 & CL-611 - Description. Battista, O. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. . Have an order or account question? };khd5x=fr . AVICEL RC 581. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C
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g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Alginates also function as actives in some anti-reflux products. Microcrystalline Cellulose Side Effects. pH 6.0 to 8.0 . Gloves, eye protection and a dust mask should be used. No. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Page 1 of 8. stream In 1964 FMC, Corporation . Avicel PC 611 Microcrystalline Cellulose. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. PharmaCentral 2021 . stream
More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. Microcrystalline Cellulose NF. POLYOX resins are nonionic polyethylene oxide solubility polymers. PDF (28.38 mb) 2022 Corporate Fact Sheet. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. We know that our customers need to provide reliable and consistent products to their patients. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.)
undefined. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Go to Investor Relations. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. <>
The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. CAS #: 9004-34-6 It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. q9;v80q>jZ The 'Substance identity' section is calculated from substance identification information from all ECHA databases. 1.3. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. /Resources 2 0 R
TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q
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U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Production of Pharmaceutical Grade Microcrystalline Cellulose. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. stream
130. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. 1. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Performing this action will revert the following features to their default settings: Hooray! Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . These grades have particle sizes ranging from <30 to approximately 200. >>
Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Dyvo5bp#bR W7~IF C"
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;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. <<
Well-recognized product that can do it all. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective.
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